Gene duplicate holds back its sister

Lupus: mysterious disease holds its secrets tight.

The early stages of duplicate gene evolution.

Gene duplications are one of the primary driving forces in the evolution of genomes and genetic systems. Gene duplicates account for 8-20% of the genes in eukaryotic genomes, and the rates of gene duplication are estimated at between 0.2% and 2% per gene per million years. Duplicate genes are believed to be a major mechanism for the establishment of new gene functions and the generation of evol...

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Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy.

The most remarkable outcome of a gene duplication event is the evolution of a novel function. Little information exists on how the rise of a novel function affects the evolution of its paralogous sister gene copy, however. We studied the evolution of the feminizer (fem) gene from which the gene complementary sex determiner (csd) recently derived by tandem duplication within the honey bee (Apis)...

The piggyBac transposon holds promise for human gene therapy.

E ver since their molecular isolation in eukaryotic organisms, transposons have been precious implements of the geneticist’s toolkit. The properties that make transposons so useful are their ability to move from one chromosomal position to another and the relatively minimal requirements for transposition to occur in the test tube and in living cells (1). In particular, transposons can be harnes...